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Research Scientist, Drug Metabolism

Gilead Sciences


Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation, headquartered in Foster City, California.


Gilead’s core values of integrity, inclusion, teamwork, excellence, and accountability shape our culture and are the foundation of our future success.  Challenge yourself and make a difference in the world – Being Here Matters.



Specific Responsibilities:


The primary responsibility of this position is to design and conduct experiments to understand the absorption, distribution, metabolism, excretion and transport (ADME) properties of drug candidates.  The scientist will also serve as a drug metabolism and pharmacokinetic (DMPK) representative on multidisciplinary project teams and provide guidance to solve ADME liabilities.  Supervision of laboratory scientists may also be required.



Essential Duties and Job Responsibilities:

  • Serve as DMPK subject matter expert on dynamic cross-functional teams, to define ADME strategy to achieve target product profile, provide in vitro and in vivo drug disposition data, interpretation, and presentations to teams.
  • Work closely with internal and external resources to assure a high level of quality and timely delivery of DMPK support.
  • Design and perform complex PK analysis, model development and PK/PD analyses to answer translational questions and to provide DMPK guidance for project teams.
  • Provides clear verbal communication of results and strategies at group, department, project team and management level.  Writes research reports and regulatory documents. 
  • Contributes to science through conference presentations and publication of new findings.
  • Supervising research associates may be required.



  • Requires a highly motivated individual with PhD degree in Pharmacology, Biochemistry, Drug Metabolism, or a related life sciences degree with 0-5 years of post-doctoral and/or industry experience in small molecule development.
  • Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
  • Requires hands-on experience and deep knowledge of pharmacokinetics, biotransformation, enzymology, transporter sciences or related pharmacology.
  • Expertise and experience in one or more of the following areas:
    • State of the art bioanalysis by LC/MS and related techniques
    • Metabolite identification and reactive metabolite chemistry
    • Biochemical and cell-based approaches to study the metabolism and/or transport of drug candidates
    • Principals, theories and approaches to understand pharmacokinetics, drug disposition and drug interactions.  Application of modeling methods for quantitative translation using software packages.
    • Bioanalysis and disposition processes of therapeutic proteins


Location: Foster City, CA


Post Date: 2/19/2019 5:34:16 PM
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