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Scientist/Sr. Scientist Small Molecule - In Vitro DMPK



Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Scientist/Sr. Scientist Small Molecule - In Vitro DMPK

We are seeking an exceptional individual for a Scientist position within the In Vitro ADME group in the Small Molecule DMPK Department at Genentech.  The successful candidate will have a strong experimental background with an established track record of hands on in vitro ADME assay support and technical problem solving.  A true experimentalist, the successful candidate has experience supporting and influencing projects with in vitro data describing metabolic stability, protein binding and DDI potential in drug discovery and/or development.  At the senior level, this person will also help guide in vitro assay development and troubleshooting as well as analytical method problem soloving (LC- MSMS). They would work with our established team to deliver data and guidance to projects in our diverse portfolio that includes oncology, cancer immunology, neuroscience, immunology, and infectious disease targets.


Who You Are

Ph.D. or in Biological Sciences/Chemistry or related field with 5-15 years of relevant pharma/biotech industry experience.  Must be highly motivated, organized, detail oriented with excellent communication skills (both oral and written), and a good team player able to interact with a diverse group of people.

  • Strong understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment is critical.

  • In depth experience with in vitro ADME assays and LC-MSMS is required.

  • Experience working with project teams to guide them through ADME problem solving using in vitro data would be preferred.

  • Experience in writing and reviewing in vitro reports for regulatory filing is highly desired.

  • Experience with automation and liquid handling systems would be a plus.

  • Advanced cell culture techniques (co-culture, MPS etc) would also be a plus.

  • For the senior level position, a track record of strategic scientific leadership in the in vitro ADME field and experience managing, coaching and developing people will be required.

A Job with Benefits Beyond the Benefits

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

Click Here to Apply


Location: South San Francisco


Post Date: 5/7/2019 12:00:00 AM
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