Regulus Therapeutics Inc. (Nasdaq: RGLS) is a biopharmaceutical company located in San Diego, California leading the discovery and development of innovative medicines targeting microRNAs.

We are currently seeking an experienced Senior Research Associate/Scientist, Drug Metabolism and Pharmacokinetics to support our team. For more information, visit www.RegulusRx.com.

Regulus Therapeutics Inc. (Nasdaq: RGLS) is a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs.  Regulus has leveraged its oligonucleotide drug discovery and development expertise to develop a well-balanced microRNA therapeutics pipeline complemented by a rich intellectual property estate to retain its leadership in the microRNA field.  Regulus is advancing several programs in renal, hepatic and central nervous systems diseases. 

Regulus is located in La Jolla, California and is led by a seasoned executive team experienced in corporate management, business, science, drug discovery and development. Regulus' scientific advisory board consists of world-class scientists and some of the foremost authorities in the field of microRNA research.

For immediate consideration, please apply to careers@regulusrx.com

You can visit our website to find out more about our company and culture: www.RegulusRx.com.

NO PHONE CALLS PLEASE.  PRINCIPALS ONLY

Regulus Therapeutics, Inc, is proud to be an EEO Employer.

Senior Research Associate/Scientist, Drug Metabolism and Pharmacokinetics

Position description and scope:

The successful candidate will be a member of the drug metabolism and pharmacokinetics (DMPK) Team and be involved in supporting in vivo studies of oligonucleotide-based drug candidates to understand the uptake of oligonucleotides into plasma and tissues as well as their metabolism.  The initial focus will be quantitation of drug levels in plasma and tissue.  This requires the candidate to be well versed and open to learning techniques employed in both bio-analytics and molecular biology, particularly analytical HPLC methods (HPLC-MS, HPLC-Fluorescence).  Experience with quantitative analysis and reporting of pharmacokinetic (PK) data is highly desired.

Position Requirements:

• BS/MS/PhD in Biochemistry or Analytical Chemistry; BS with at least 5 - 8 years of industrial experience; Ph.D. with at least 3 years of industrial experience.

• Experienced with analytical HPLC and in particular HPLC-MS.
• Effective interpersonal skills, including both written and oral communication skills.
• Self-motivated, ability to work independently while also willing to follow protocols, resourcefulness, and innovative thinking.
• Strong analytical skills, highly attentive to details, and strong work ethic.
• Ability to work within schedules and deadline.
• Ability to multitask, prioritize, and function in a fast-paced, dynamic environment.

• Hands-on experience with quantitative analysis and reporting of bioanalytical data.
• Hands-on experience with sample extraction from tissue and plasma.
• Ability to quickly learn new data-analysis software and efficiently manipulate large datasets in Excel.
• Willingness to learn existing techniques outside one’s field and to introduce new techniques.

• Strong work ethic, attention to details and good organization skills.
• Will work on assignments that are complex in nature where considerable judgment and initiative are required in resolving problems and making recommendations.
• Demonstrated ability to think critically and to work independently as well as in a team setting.

Skills desired:

• Track record of developing or preforming in vitro DMPK assays.
• Thorough understanding of PK concepts in theory and practice, experience with running PK simulations and modeling.
• Proficient in WinNonLin Software, R-programming, and/or Python.
• Experience with running and/or development of ELISA assays.