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Position:
Associate Director, Discovery DMPK
Employer:
DiCE Molecules
Description:
We are currently seeking an Associate Director/Principle Scientist, Drug Metabolism and Pharmacokinetics/Bioanalytical, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the qualitative and quantitative in vitro and in vivo PK/ADME bioanalytical assays.
The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and execute assays/studies necessary to address key program DMPK issues in order to successfully advance research compounds into development.
Qualifications/Experience:
Essential Functions:
Provide scientific DMPK leadership and strategic direction to research project teams Provide scientific oversight of PK/ADME studies placed at CROs Execute/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic and in vitro ADME analyses of novel small molecule therapeutics May supervise associate-level DMPK scientists Conduct PK and PK/PD modeling using noncompartmental and compartmental models Organize and maintain research data Present data at project team meetings Ensure that high quality research reports are completed in a timely manner
Preferred Experience and Education:
PhD in a scientific discipline or BS/MS with appropriate work experience 7-10 years (PhD) or 12-15 years (BA/MS) of postgraduate experience in an industry research and/or development environment is preferred Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills
Preferred Additional Skills:
Should be familiar with ABI Analyst, Excel, WinNonlin Phoenix and Prism Prior success demonstrating strong leadership, collaboration and influence throughout the organization Prior management experience of Research Associates and/or Scientists is a plus Strong bioanalytical method development skills (HPLC and LC/MS/MS) Experience conducting microsomal, plasma and whole blood stability determinations, metabolite profiling, CYP and transporter inhibition studies, and plasma protein binding analyses Be able to work independently and in a cross-functional team environment Must have solid knowledge and demonstrated hands-on experience in qualitative and quantitative bioanalysis and in vitro assay development Strong verbal, written communication and relationship skills including success managing external vendors Excellent interpersonal and organizational skills Engaged in LC/MS/MS instrument maintenance and repair Detail-oriented and have an in-depth understanding of industry trends Success operating in a fast-paced, dynamic environment Current US work authorization required Ability to travel domestically
Location:
San Francisco Bay Area
Contact:
joanna@christinemathews.com
Post Date:
1/27/2020 12:00:00 AM
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