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Associate Director, Discovery DMPK

DiCE Molecules


We are currently seeking an Associate Director/Principle Scientist, Drug Metabolism and
Pharmacokinetics/Bioanalytical, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the qualitative and quantitative in vitro and in vivo PK/ADME bioanalytical assays. 

The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and execute assays/studies necessary to address key program DMPK issues in order to successfully advance research compounds into development.


Essential Functions:

 Provide scientific DMPK leadership and strategic direction to research project teams
 Provide scientific oversight of PK/ADME studies placed at CROs
 Execute/manage quantitative bioanalysis of plasma and other biological matrices to support
pharmacokinetic and in vitro ADME analyses of novel small molecule therapeutics
 May supervise associate-level DMPK scientists
 Conduct PK and PK/PD modeling using noncompartmental and compartmental models
 Organize and maintain research data
 Present data at project team meetings
 Ensure that high quality research reports are completed in a timely manner

Preferred Experience and Education:

 PhD in a scientific discipline or BS/MS with appropriate work experience
 7-10 years (PhD) or 12-15 years (BA/MS) of postgraduate experience in an industry research and/or development environment is preferred
 Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills

Preferred Additional Skills:

 Should be familiar with ABI Analyst, Excel, WinNonlin Phoenix and Prism
 Prior success demonstrating strong leadership, collaboration and influence throughout the organization
 Prior management experience of Research Associates and/or Scientists is a plus
 Strong bioanalytical method development skills (HPLC and LC/MS/MS)
 Experience conducting microsomal, plasma and whole blood stability determinations, metabolite profiling, CYP and transporter inhibition studies, and plasma protein binding analyses
 Be able to work independently and in a cross-functional team environment
 Must have solid knowledge and demonstrated hands-on experience in qualitative and quantitative
bioanalysis and in vitro assay development
 Strong verbal, written communication and relationship skills including success managing external vendors
 Excellent interpersonal and organizational skills
 Engaged in LC/MS/MS instrument maintenance and repair
 Detail-oriented and have an in-depth understanding of industry trends
 Success operating in a fast-paced, dynamic environment
 Current US work authorization required
 Ability to travel domestically

Location: San Francisco Bay Area


Post Date: 1/27/2020 12:00:00 AM
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