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Position:
BS-MS Associate, Biomarker Imaging
Employer:
PTC Therapeutics
Description:
The BS-MS Associate II, Biomarker Imaging will determine the cellular abundance and localization of biomarkers in situ using novel imaging modalities. The candidate will join a diverse team responsible for the delivery of high-quality biomarker data elucidating the mechanism of action and disease pathology in both genetic and pharmacologically induced pre-clinical models of human disease. This position will be instrumental in the group’s efforts to provide evidence of target engagement across the PTC Therapeutics pipeline with a particular interest in neurodegenerative programs. The incumbent will be responsible for communicating experimental results to his/her supervisor and working cross-functionally across multiple departments.
Primary responsibilities include:
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Independently carries out grossing, orienting, and cryo-embedding research tissues
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Maintain diagnostic viability of all specimens received and ensure correct labeling of all materials
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Responsible for cryo-sectioning and thaw-mounting fresh frozen tissues
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Perform rapid H&E or Cresyl Violet staining to quickly assess tissue coordinates and architecture
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Prepare and maintain tissue fixatives and reagents/solutions for staining of tissue sections
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Utilize an automated spray-coating device for high-resolution tissue derivatization and matrix applications compatible with imaging mass spectrometry
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Conduct IHC, ICC, and IF to determine the localization of biomarkers and/or pharmacological targets
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Scan and image stained slides for analysis (bright field, fluorescence and/or confocal)
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Perform digital image analysis using various computer programs such as FlexImaging or ImageJ
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Aid in non-histological experiments in support of in vitro and ex vivo biomarker quantitation for pre-clinical studies (e.g. tissue processing for quantitation of lipids, DNA oxidation, etc.)
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Keep records of laboratory protocols and maintenance of equipment in an ELN
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Demonstrates compliance with corporate, departmental, and job-specific requirements
Qualifications/Experience:
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Bachelor’s degree in a scientific discipline with a minimum of 2 years of relevant experience
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Skilled at cryo-sectioning and thaw mounting fresh frozen tissues
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Experience with tissue and/or cell staining protocols
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Proficiency with Microsoft Office
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Excellent verbal and written communication and skills
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Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines
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Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects
- Previous experience with whole-body cryo-sectioning a plus
- Working knowledge of sample preparation for imaging mass spectrometry preferred
Location:
Mountain View, CA
Contact:
https://ptcbio.wd5.myworkdayjobs.com/PTC_Careers/job/USA---California---Mountain-View/BS-MS-Associate---Biomarker-Imaging_R1310
Post Date:
12/16/2020 12:00:00 AM
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