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SUMMARY: Exelixis is seeking a highly self-motivated, interactive, and productive hands-on PhD scientist to join the Pharmacology team working towards discovery of anti-cancer agents for the treatment of targeted indicati

Senior Scientist I (Pharmacology, PD/Efficacy)



  • Design, execute and interpret in vivo pharmacology experiments to test the selected compounds in rodent models of cancer.
  • Establish efficacy/PK/PD relationship; characterize toxicity profile for the preclinical therapeutic candidates.
  • Utilize literature and internal data sets to design and test hypotheses for drug targets.
  • Represent Pharmacology function on discovery teams and lead sub-teams.
  • Provide scientific support for the project teams and Discovery/ Pharmacology staffs.
  • Prepare technical reports for research findings and IND filings.
  • Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.


  • May manage a team of PD/Efficacy members in the Pharmacology group




  • PhD in Pharmacology, Cancer Biology, Molecular Cellular Biology or a closely related field with four to six years of industrial experience after post-doctoral trainings


  • A broad understanding of in vitro and in vivo Pharmacology, PK, PD concepts within the cancer biology field is essential.
  • Extensive experience using in vivo oncology models for drug discovery with proven track record in establishing, validating and implementing animal models for testing cancer therapies including xenograft, syngeneic, genetically engineered mouse, orthotopic, PDX and humanized models to study biologic mechanisms.
  • Proven track record of writing regulatory and IND filing documents in the pre-clinical Pharmacology section.
  • Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale.
  • Expertise in cell culture with aseptic technique is a must.
  • Experience in utilizing imaging modalities in tumor research is desired.
  • Experience with immunophenotyping of cells from in vivo studies is preferred.
  • Strong scientific expertise with good track records of publications.
  • Managerial experience related in in-vivo pharmacology personnel is required.


  • In vivo skills include but not limited to animal handing, dosing with different routes (po, iv, sc, ip etc.), blood collection, tissue collection/ perfusion, necropsy, tumor measurement, clinical observation and rodent survival surgeries.
  • Has flexibility to accommodate to fast-paced work environment and deadlines.
  • Works independently; self-motivated and innovative.
  • Ability to work in a team-based environment and coach junior scientists.
  • Excellent oral and written communication and presentation skills in English.
  • Detail oriented and able to problem solve and offer potential solutions.
  • Good understanding in laboratory bench skills such as Mesoscale, Luminex, qPCR, Flow cytometry, and/or histology is required; capability of running ELISAs and Western blots is a plus.
  • Advanced knowledge of Excel, Word, PowerPoint, PDF, Graphpad prism is required.  Capability of using Studylog, Freezerworks, ELN notebook and Biovia Insight is preferred.


Location: Alameda, CA


Post Date: 12/22/2020 2:06:26 PM
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