Jobs
View more job listings or post a job
UC Davis / Equine Analytical Chemistry Laboratory CONFIRMATION CHEMIST (Job Opening #19590)
Denali Therapeutics Bioanalytical Scientist, DMPK
Bioduro-Sundia Associate Director in in-vitro ADME
Bioduro-Sundia Director of PK and TK
Genentech Scientific Researcher/Senior Scientific Researcher, Biotransformation
Genentech Scientist
VIR Biotechnology Scientist, DMPK
Janssen R&D (J&J) Scientist - DMPK In Vitro ADME
QED Therapeutics, a BridgeBio company Clinical Pharmacology Scientist/Sr Scientist
PTC Therapeutics Scientist I - Translational Omics
Post a job


Position:
Scientist I - Translational Omics

Employer:
PTC Therapeutics

Description:

The Scientist I, Translation Omics will use cutting edge analytical techniques, with a focus on mass spectrometry, to identify new biological targets, verify compound engagement and ascertain pharmacodynamic effects across the PTC Therapeutics pipeline. The candidate will join a diverse team employing multi-omics approaches to interrogate both cellular metabolism/flux as well as systems level biological changes associated with genetic and/or disease phenotypes.

Primary duties and responsibilities will include: 

  • Create and optimize quantitative LC-MS based targeted assays (SRM/MRM) across a diverse range of biomarker classes.
  • Develop new and improve upon existing sample preparation procedures for LC-MS assays conducive to multi-omics analyses of cellular systems, biofluids, and tissues.
  • Expand existing biomarker assays to greater cover targeted disease pathways.
  • Integrate and visualize multi-omic datasets to elucidate changes in dynamic biological systems.

The Scientist I, Translation Omics is responsible for planning and performing scientific experiments that contribute to PTC’s research and drug discovery activities. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams.

The Scientist I, Translational Omics supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.



Qualifications/Experience:
  • Extensive hands-on experience with both targeted (QQQ) and high resolution (FTICR, Q-ToF, etc.) mass spectrometers
  • Detailed knowledge of separation techniques for small and large molecules with applied experience on chromatography systems in multiple flow regimes (e.g. micro and nano)
  • Experience with developing isolation, enrichment, and purification strategies for both rare and less stable analytes in multiple biological matrices
  • Capable of working with large datasets, proficient in data processing/reduction strategies, and experience with both statistical and visualization software packages
  • Prior use of isotopically labeled workflows (e.g. SILAC, iTRAQ, etc.) to measure cellular flux and/or quantitate multi-omics changes without a priori knowledge is preferred
  • While multi-omics experience is preferred, exceptional candidates focusing on a single omics field (e.g. metabolomics, spatial-omics,  lipidomics, phosphoproteomics, etc.) will be considered


Location: Mountain View, CA

Contact: jlatham@ptcbio.com

Post Date: 4/28/2021 12:56:47 PM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 6/25/2021; Admin Logon
Ads (in random order)
Submit a Text Ad
($250 for 2 months)

Alturas Analytics, Inc. Expert GLP & non-GLP LC-MS/MS, GC-MS/MS bioanalytical & PK/TK analysis services of small & large molecules in any matrix. Discovery through phase IV.
Hypha Discovery Ltd. Synthesis, purification & NMR characterization of drug metabolites at mg-g scale with COAs, including CYP/AOX/FMO metabolites, glucuronides & sulfates
Submit a Text Ad