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Scientist I/II-DMPK

Aligos Therapeutics


TBH# (To Be Hied): TBH1
FLSA Classification: Exempt
Department: DMPK
Company Overview:
Aligos Therapeutics, Inc. is a biotechnology company located in South San Francisco, California that is developing novel medicines to treat liver diseases in virology, inflammation/fibrosis and oncology. Aligos is pursuing the development of both oligonucleotide-based and small molecule therapeutics, with the goal of becoming a world leader in the development of targeted, antiviral therapies for CHB and COVID-19 and to leverage our expertise in liver diseases to create targeted therapeutics for NASH.
At Aligos, our science is the key to our success, and to improving patients' quality of life. Our pipeline of developing novel compounds and investigative therapies reflects our commitment to bring innovative products to patients with unmet needs in the area of liver diseases. This is an exciting opportunity to become an early employee of a high energy, Research and Development company. We are looking for an enthusiastic professional who understands and appreciates the entrepreneurial environment of a “start-up” and who is willing to do what it takes to contribute to the success of the company.
Position Summary/About the Team: This position will report to Senior Director DMPK and be responsible for providing DMPK support for new chemical entities. The scientist will work closely with the functional leads to support drug discovery and development teams. The position will have high visibility within the company and is expected to contribute directly to the company’s goals and objectives.


Essential Functions / Responsibilities:
• Support discovery project teams for candidate selection and lead optimization.
• Design, conduct and interpret in vitro and in vivo DMPK studies.
• Determine PK parameters for nonclinical studies using WinNonlin and assist with the application of modeling approaches (in silico, PK, PBPK) to support human pharmacokinetics and dose predictions, quantitative risk assessment of drug-drug interactions.
• Monitor and manage studies that are conducted at contract research organizations.
• Generate, analyze and present data, both orally and as written reports.
• Author reports and various regulatory documents that are required for worldwide regulatory submissions.
Reasonable accommodations may be made to enable individuals with disabilities to perform these essential functions.
Required Education and Experience:
• PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule pharmacokinetics and metabolism with 0-3 years of experience.
• Hands on experience with in vitro assays and/or in vivo DMPK studies.
• Robust knowledge of DMPK principles.
• Postdoctoral training in the DMPK field highly desired.
• Proven skills in pharmacokinetic data analysis using Phoenix WinNonlin.
Preferred Education and Experience:
• Familiarity with NONMEM, SimCyp and/or Gastroplus PBPK modeling.
Additional Eligibility Qualifications/Competencies
• Ability to adapt quickly, succeed in a team environment and learn new tasks independently.
• Excellent interpersonal and communications skills, ability to build productive internal/external working relationships with cross-functional teams.
• The successful candidate must be flexible and adaptable to the needs of a small company.
• The ability to multitask and prioritize to delivery results within tight timelines is a must.
Work Authorization/Security Clearance
All candidates are expected to have authorization to work in the United States.
Supervisory Responsibility
Manage and guide CRO’s.
Position Type and Expected Hours of Work
This is a full-time position. Expected days and hours of work are Monday through Friday, 40 hours per week.
Physical Requirements
• Work with a laptop and/or desktop computer in a seated or standing manner, for long periods (2+ hours at a time). Must be able to use standard computer input devices (e.g., mouse and keyboard).
• Work with a variety of screens, all of which read out in English.
This position is located in South San Francisco, CA and may require approximately 5% travel.
Other Duties:
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for their job. Duties, responsibilities and activities may change at any time with or without notice.
Work Environment
This position works in both a standard office setting as well as in a functional laboratory, with specialized laboratory equipment. While in the laboratory, employees may be exposed to a number of potentially hazardous chemicals, which are used in the usual course of experimentation. While in the laboratory, employees will be expected to wear appropriate safety equipment, including a lab coat, gloves, goggles and mask. Appropriate precautions and safety measures are to be followed.
EEO Statement:
Aligos Therapeutics, Inc. is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy
(including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to

Location: South San Francisco


Post Date: 6/29/2021 10:24:58 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 8/4/2021; Admin Logon
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