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Sr. Scientist, DMPK

Circle Pharma

Circle Pharma is a pre-clinical stage, life sciences company discovering and developing macrocycle therapeutics, with an initial focus in oncology.  Our discovery platform allows us to address challenging therapeutic targets such as intracellular protein-protein interactions. 
We seek candidates who desire to make key contributions to help drive our growth.  For more information about Circle Pharma, please see our website,
Circle Pharma is seeking a highly motivated DMPK Scientist, working out of our headquarters in South San Francisco. Our successful candidate will be responsible for designing, implementing, and interpreting in vitro and in vivo studies to understand adsorption, distribution, metabolism, and excretion (ADME) as an integral part of the drug discovery team, to drive forward development candidate selection into clinical development. As a member of multiple project teams, you will collaborate to define target product profiles, identify ADME issues/solutions, align pharmacokinetics and pharmacodynamics, and facilitate the rapid advancement of development candidates. Active participation in establishing DMPK strategy and tactical planning along with in-house and external execution, outsourcing, monitoring, and reporting nonclinical studies while ensuring high-data quality for regulatory submissions is a key function of this job.
This role offers the opportunity to play a key role in a strong multi-disciplinary scientific team while tackling important and challenging therapeutic targets, at a company with world-class scientific advisors and robust financial backing from top-tier investors.  Our ideal candidate will have a track-record of excellence participating in teams taking molecules from pre-clinical lead optimization to IND enabling studies and into clinical studies and will have the aptitude for working in collaboration with our existing drug discovery core groups. This position is not a remote position, and requires regular, consistent presence at our site in South San Francisco.

What You'll Do:

    • Support overall scientific, technical, and operational efforts supporting DMPK across the project portfolio
    • Provide scientific guidance on lead optimization and work in close collaboration with colleagues to optimize and evaluate the DMPK properties of candidate drugs
    • Manage and contribute to the design internal/external DMPK studies and be responsible for oversight and deliverables from external studies. Strong Data management skills will be required to manage multiple incoming data streams and their interpretation and dissemination to project teams and databases
    • Active voice in the preclinical assessment of the ADME properties of lead molecules and development candidates
    • Provide robust data to facilitate IND enabling preclinical PK packages supporting evidence based clinical dose projections
    • Analyze, interpret, integrate and report nonclinical DMPK data generated with external vendors/CROs
    • Make a fast “no” decision to maintain focus on productive endeavors, when appropriate
    • Own scientific/technical aspects as well as management of studies including protocol development, oversight of outsourced activities, data analysis/interpretation, and report writing

    • Doctoral degree in pharmacokinetics, pharmaceutics, or related discipline with 3+ years of experience in the biopharmaceutical industry. Alternatively, the candidate may have a Master’s degree and 7+ years of experience in the biopharmaceutical industry, or a Bachelor’s degree and a 10+ years of experience in the biopharmaceutical industry
    • A strong background in DMPK and pharmacokinetics/pharmacodynamics as applied to small molecule drug discovery and experience with covalent-drug molecules
    • Extensive knowledge of metabolic routes of biotransformation, metabolite identification, and the chemistry of drug metabolism, required
    • Technical knowledge in multiple DMPK areas coupled with an in-depth understanding of the experimental DMPK methodologies and approaches utilized in optimizing the ADME properties of small-molecule oral drugs
    • Experience in design and interpretation of multi-species PK and methods to model human dose/exposure a plus
    • Able to make a fast “no” decision to maintain focus on productive endeavors
    • Strong interpersonal and communication skills including exceptional collaboration and relationship management skills
    • Good knowledge of current regulatory guidelines
    • Independent researcher with excellent time and people management capabilities seeking to contribute meaningfully and lead cross-functional teams to support the company's drug discovery projects
    • Proficient in the use of WinNonLin, NONMEM, GastroPlus/ADMET Predictor®
    • Committed to excellence, ensuring fellow team members focus on high quality science within a professional working environment
    • Legally authorized to work in the US for any employer
Circle Pharma is a dynamic start-up company, and our successful candidate must have the ability and desire to work in a fast-paced environment. Circle offers a comprehensive compensation package, as well as generous paid time off, in addition to Company observed holidays.  The Company provides Medical, Dental and Vision Insurance, along with a retirement savings plan which includes employer contributions.  We promote a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork. 
Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.

Location: South San francisco


Post Date: 7/7/2022 12:00:00 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 10/7/2022; Admin Logon
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