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Position:
Research Associate - Molecular and Cell Biology

Employer:
Peak Bio

Description:

Peak Bio is a newly created venture out of the San Francisco Bay Area that will soon reach a critical milestone in our history of going public on NASDAQ. We are seeking scientific and business talent at two of our critical sites that include our center of research excellence in Palo Alto, California and our G&A infrastructure in South Florida.

Peak Bio is a clinical-stage biopharmaceutical company focused on commercializing innovative therapeutics that aim to improve and address significant unmet medical needs for patients with inflammatory, rare and specialty diseases and cancer. We seek qualified, energetic, and talented individuals with a desire for growth, and advancement but with a knack for working in a cross-cultural, team-based environment. The talent we seek works well with others and knows that, in the end, the company’s overarching goal is to improve the human health experience and help solve the medical mysteries that challenge us daily. As a company we will continue to explore, work closely with and partner with external researchers, clinicians, patient advocacy groups, academic institutions, governmental agencies, and our investors to continue to expand treatment options and partnerships to meet those expectations and find novel approaches to treat disease.

This is a full-time position based in our Palo Alto, California offices, and will initially report to the Head of Oncology.

This role will be important in driving the future of our business, demonstrating the ability to work scientifically with a unique business model, working collaboratively amongst other talented scientists who utilize expertise, analytics, creativity and ingenuity to succeed.

Key Responsibilities

  • Perform PCR and molecular cloning of antibody and His or Fc-tagged target protein extracellular domain (ECD) constructs
  • Perform plasmid purification and screening of recombinants
  • Maintain cell culture
  • Produce protein characterization (affinity determination, competitive binding assays, epitope determination) by plate-based methods (ELISA)
  • Construct SDS-PAGE and Western Blotting
  • Implement transfection of CHO cells and transient pool/ stable clonal analysis of antibody production as well as generation of stable engineered cell lines and expression analysis
  • Perform flow cytometry
  • Perform in vitro potency assays and/or antibody-related binding/internalization assays
  • Perform cell-based assays per SOP/ investigator guidance

 



Qualifications/Experience:

Desired Abilities and Qualifications

  • BS in molecular biology, cell biology or related science with 4+ years of relevant industry experience or MS in above disciplines with 2+ years of relevant industry experience
  • Performs well in a highly matrixed environment
  • Collaborative presence, working closely with-
    • antibody engineering team, generating recombinant antibodies by molecular cloning
    • antibody engineering team, screening for antibodies or plasma/hybridoma cells of interest
    • target validation team, identifying antibodies with desired properties
    • target validation team, performing cell-based assays per SOP
    • target validation team, qualifying their cell-based assays by SDS-PAGE
    • protein production team, identifying high producer clones
    • translation team, investigating MoA by SDS-PAGE
  • Excellent documentation and organizational skills
  • Excellent interpersonal/communication skills in embodying a collaborative, respectful, courteous, capable company culture
  • Experience with antibody-drug-conjugates (ADC) a plus. 
  • Experience with transient mammalian (CHO and HEK) antibody or other protein expression a plus

 What you will enjoy while working with us

(Any or all of these benefits are subject to change at any time at Peak Bio’s discretion).

  • Competitive Pay
  • Bonus Eligibility
  • Stock Option Eligibility
  • Health Care Plan
    • Medical
    • Dental
    • Vision
  • 401(k) Plan
  • Family Leave (Maternity, Paternity)
  • Life Insurance
  • Long- and Short- Term Disability
  • Generous PTO Policy
  • Paid Company Holidays

Does Peak Bio’s mission and unique business model ignite your passion and interest?  Does the opportunity to work alongside talented and welcoming team members make you want to join?  Do the responsibilities and qualifications translate very similarly to what you have to offer?  Does the overall benefits package make you feel valued and appreciated?  If you answer “yes” to these questions, we definitely want you to apply.

Job candidates should be aware that full vaccination against COVID-19 is required as a condition of employment subject to legally required exceptions. Peak Bio is an equal opportunity employer and encourages potential or current employees to request a reasonable accommodation under federal, state and local regulations, should one be needed.

Please apply using the following link: https://peakbio.bamboohr.com/jobs/view.php?id=61&source=aWQ9MTE%3D

 

 

 

 



Location: Palo Alto, CA

Contact: Maja: 408-781-7387

Post Date: 8/31/2022 12:00:00 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 10/7/2022; Admin Logon
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