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 Senior Scientist 1/ Senior Scientist 2, DMPK

Aligos Therapeutics, Inc.


This position will report to Senior Director DMPK and be responsible for providing DMPK expertise for new chemical entities, small molecule and oligonucleotides, as a project representative on multi-disciplinary drug discovery and development teams.  The position will have high visibility within the company and is expected to contribute directly to the company’s goals and objectives.

Essential Functions / Responsibilities:

  • Work closely with nonclinical discovery scientist, clinicians and cross-functional project team members. Participate as functional representative on discovery/development project teams.
  • Provide leadership and guide discovery project teams for candidate selection, develop and drive DMPK strategies for lead optimization and solving ADME-related issue. Design, conduct and interpret in vitro and in vivo DMPK studies.
  • Determine PK parameters for nonclinical studies using WinNonlin and assist with the application of modeling approaches (in silico, PK, PBPK) to support human pharmacokinetics and dose predictions, quantitative risk assessment of drug-drug interactions.
  • Generate, analyze and present data, both orally and as written reports.
  • Author and review various regulatory documents that are required for worldwide regulatory submissions.    


Required Education and Experience:

  • PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule and oligonucleotide pharmacokinetics and metabolism with 0 to 3 years of relevant industry experience.
  • Proven expertise in conducting in vitro and/or DMPK studies.
  • Proven track record of scientific/technical writing and presentation.
  • Knowledge of drug development and regulatory guidelines.

Location: South San Francisco


Post Date: 4/13/2023 12:00:00 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 6/7/2023; Admin Logon
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