Speakers: Sven Hackbusch, Thermo; Gabriel Bracamontes, Evosep; Frederick Strathmann, MOBILion; Jim Lau, Agilent; Daojing Wang, Newomics; Eshani Galermo, Sciex; Stephen English, Pharmaron
Organizers: John Mehl (Agilent), Keyang Xu (Genentech)
Date: 2024-12-05
Time: 8:30-13:05 Pacific Time
Registration fee: 0
Location: Online via Zoom
Major Sponsor: (1)Thermo Fisher Scientific
Vendor show vendors registered to date:
Registration: http://www.PBSS.org
Registration deadline:2024-12-04  (it will close sooner if the seating cap is reached)

About the Topic

The scope of mass spectrometry applications in life science and drug development has broadened significantly in recent years, thanks to continuous scientific innovation in MS and related technologies. For instance, quantitative MS-based or hybrid LC-MS bioanalytical assays are developed routinely to assess pharmacokinetic exposure in regulated studies, as well as measure biomarkers for target engagement, pharmacodynamic or safety effects. In addition, characterization of reference materials, catabolites and metabolites (both in vitro and in vivo), immunogenicity, and other parameters can also be achieved using MS-based approaches. Needless to say, limitations, challenges and new demands are identified in the process, which can be addressed via introduction and implementation of novel technologies in MS and peripheral devices. In this symposium, we aim to showcase some recent concepts and developments, primarily from instrument manufacturers/vendors, to further enhance MS-based assay performance, throughput, and problem-solving capabilities. Case studies will highlight faster and cleaner sample preparation, more selective analyte separation, robust/reproducible ionization and transmission, radiolabeled microtracer approach, complementary multiplexing ion detection, and optimized data handling in support of drug development of both small and large molecules.