Speakers: Cyrus Khojasteh, PhD (Genentech), Bill Fitch, PhD (independent consultant), Shichang Miao, PhD (ex-Chemocentryx/Amgen), Raju Subramanian (Gilead)
Organizers: Cyrus Khojasteh, PhD (Genentech), Bill Fitch, PhD (independent consultant), Shichang Miao, PhD (ex-Chemocentryx/Amgen)
Date: 2025-04-25
Time: 8:45-17:00 Pacific Time
Registration fee: Regular attendees: $295; Academic/Students/Postdocs/Out-of-Pocket: $45; Major Sponsorship: $3000; Vendor Show: $695, Happy Hour Sponsorship: $975; Lunch Sponsorship: $1250; On-site Registration: $500
Location: Crowne Plaza, Foster City, CA (San Francisco Bay Area)
Major Sponsor:
Vendor show vendors registered to date:
Registration: http://www.PBSS.org
Registration deadline:2025-04-24  (it will close sooner if the seating cap is reached)

About the Topic

Drug Metabolism, a process by which the body converts a drug into metabolites generally favoring excretion, is a major clearance mechanism for drugs and plays a key role in a drug’s pharmacokinetic and pharmacodynamic profiles. Identification of the metabolites is a major component in drug metabolism studies and is critical for both drug discovery and drug development. At the discovery stage, when metabolic stability becomes an issue for the compound’s PK profiles, the medicinal chemists would demand the identification of the precise structural locations of the metabolic modifications, so that analog compounds can be designed to address the metabolic liability issue. For the development stage, it is critical to know the metabolites and the metabolic pathways of the drug as the metabolites can also play some biological and pharmacological roles such as efficacy, toxicity and drug-drug interaction. This workshop will discuss the fundamentals of drug metabolism, commonly used methods for studying drug metabolism, and techniques for identifying metabolites.

List of Topics:

• Fundamentals of drug metabolism and drug metabolizing enzymes (including phenotyping)
• Metabolite identification overview, metabolite isolation and separation techniques
• MS/MS interpretation
• NMR techniques for metabolite identification
• Metabolism and metabolite identification for new modalities (ADCs, PROTACs and Oligos)
• In vivo metabolite profiling and case studies