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Genentech Senior/Principal Scientific Researcher (Cell-based Assay Development), BioAnalytical Sciences Department, Genentech
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Position:
Senior/Principal Scientific Researcher, DMPK LC-MS Bioanalysis

Employer:
Genentech

Description:

Join a Team that Lives to Improve Lives

People come to Genentech from across disciplines and across the world to solve our
most challenging medical conditions. You’ll find inspiration in our passion for
biotechnology, our purpose to positively impact the lives of millions of patients and our
dedication to our people. Joining Genentech means being part of a tradition of inquiry
that will change the world. It means embracing our failures as much as our successes.
It requires a willingness to look beyond the edge of what's possible. And a focus on
doing the day-to-day work that makes great science happen.

The following opportunity exists in South San Francisco, CA:

Senior/Principal Scientific Researcher, DMPK LC-MS Bioanalysis

Description
The Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech is
seeking a highly motivated Senior/Principal Scientific Researcher to join the
Bioanalytical (BA) function. The DMPK-BA function is primarily responsible for
overseeing regulated bioanalytical activities conducted at contract research
laboratories (CROs) and ensuring overall compliance with GLP/GCP regulations to
support the preclinical and clinical development of Genentech’s small molecule
programs.

Responsibilities include but are not limited to: technical monitoring during bioanalytical
method development, validation, and sample analysis; overseeing method transfer
between CROs; reviewing validation reports and experimental documentation; and
archiving relevant study documents. The individuals in this function also conduct CRO
evaluation and selection, review CRO SOPs, determine additional bioanalytical
requirements if needed, and perform regular site visits and inspection. Internally, the
individuals are responsible for developing highly sensitive and specific bioanalytical
methods for quantitative analysis of new chemical entities, metabolites, and biomarkers
in a variety of biological matrices, reproducing CRO-developed methods, and performing
non-regulated quantitative bioanalysis. The individuals serve as bioanalytical
representatives on interdisciplinary project teams. In addition, the individuals may
supervise and train junior staff to successfully perform all the above-mentioned
responsibilities



Qualifications/Experience:

Qualifications:

• Degree in analytical chemistry, biochemistry, or related discipline
• Bachelor’s degree with a minimum of 3 years of relevant industry experience. Or
a recent graduate from a master’s degree.
• Ability to work independently in a fast-paced environment, as well as in a team
setting.
• In-depth bioanalytical knowledge and extensive experience with modern
analytical instrument platforms, particularly with LC-MS/MS.
• Hands-on experience in developing and validating LC-MS bioanalytical methods
using various techniques (SLE, LLE, SPE, and PP)
• Ability to manage multiple studies simultaneously and be able to assist in
troubleshooting when instrument or assay problems arise.
• Good understanding of GLP/GCP regulations
• Possess excellent oral and written communication skills.
• Prior working experience at or with CROs is preferred.

Who We Are?

Genentech, a member of the Roche group and founder of the biotechnology industry, is
dedicated to pursuing groundbreaking science to discover and develop medicines for
people with serious and life-threatening diseases. To solve the world's most complex
health challenges, we ask bigger questions that challenge our industry and the
boundaries of science to transform society. Our transformational discoveries include
the first targeted antibody for cancer and the first medicine for primary progressive
multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact
on society. We believe that by championing diversity of background, thought and
experience, we can foster a sense of belonging and provide an environment where every
employee feels valued, included, and able to contribute their best for the patients we
serve. We’re focused on attracting, retaining, developing and advancing our people to
their full potential by rewarding bold ways of thinking and integrating inclusive
behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based
on race, color, religion, gender, sexual orientation, gender identity/expression, national
origin/ancestry, age, disability, marital & veteran status. For more information about
equal employment opportunity, visit our Genentech Careers page.
If you are in need of an accommodation due to a disability to assist with submitting
your application or at any point during the hiring process, please
email US.accommodation@roche.com.



Location: South San Francisco

Contact: https://bit.ly/2ZTVewQ

Post Date: 11/3/2021 8:58:09 AM
©Pharmaceutical & BioScience Society, International; Last Modified: 8/11/2022; Admin Logon
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