Vir Biotechnology is seeking a Pharmacometrician responsible for leading the pharmacometrics strategy across therapeutic areas and programs, from early clinical development to market application and commercialization.

• The candidate will join the Clinical Pharmacology department reporting to the VP of Clinical Pharmacology.
• Develops and implements model informed drug development (MIDD) plans across projects and disease areas in order to optimize prospective studies, inform drug development strategy and project decision-making, in collaboration with Project Lead Clinical Pharmacologist.
• Responsible for pharmacometrics activities (population pharmacokinetics modeling and simulations, PK/PD, exposure-response, etc) working in close collaboration with the Project Lead Clinical Pharmacologist.
• Conduct modeling and simulations activities for programs across various stages of development (pre-IND through post-marketing).
• Present modeling and simulation data, acting as a technical pharmacometrics expert on cross-functional project sub-team.
• Identifies opportunities where modeling and simulation can advance the understanding of pharmacological activity, efficacy and safety.
• Help in providing support and/or development of quantitative methodology, pharmacometrics tools, software, hardware, and related business processes.

• Ph.D. or equivalent degree with at least 10 years of experience OR MS or equivalent degree with at least 13 years of experience.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics.
• Understanding and ability to guide quantitative/modeling efforts. Experience in performing population PK/PKPD analyses using standard pharmacometric software (e.g. NONMEM, R, Monolix, Phoenix, etc.) for protein therapeutics (mAbs, siRNA, etc) and small molecule therapeutics.
• Ability to influence MIDD (model informed drug development) regulatory strategies in conjunction with the clinical pharmacology project lead.
• Strong understanding of clinical pharmacology studies to support intrinsic/extrinsic factors, ability to independently author and defend pharmacometrics components of regulatory filings.
• Interact with and/or lead modeling/simulations activities with external CROs.
• Mentor and coach junior staff within Clinical Pharmacology.